Magnetic Solid-phase Extraction of Target Analytes from Large Volumes of Urine

INTRODUCTION: Analysis of urine is often used to detect the presence or determine the concentration of various biologically active compounds or xenobiotics. Urine has become the preferred specimen since many compounds can be detected for longer time periods in urine than in blood. Furthermore, urine collection does not require phlebotomy, and urine is typically an ample and stable sample. In most cases the concentration of target analytes is low and thus the analytes have to be preconcentrated before the application of an appropriate analytical procedure.